InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF2S1

Summary

InnateDB Protein

IDBP-586107.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2S1

Protein Name

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Synonyms

EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A;

Species

Homo sapiens

Ensembl Protein

ENSP00000451975

InnateDB Gene

IDBG-9859 (EIF2S1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	59 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity

Biological Process

GO:0006413

translational initiation

Cellular Component

GO:0005850

eukaryotic translation initiation factor 2 complex

Protein Structure and Domains

PDB ID

InterPro

IPR003029 Ribosomal protein S1, RNA-binding domain
IPR011488 Translation initiation factor 2, alpha subunit
IPR012340 Nucleic acid-binding, OB-fold
IPR022967 RNA-binding domain, S1
IPR024054 Translation initiation factor 2, alpha subunit, middle domain
IPR024055 Translation initiation factor 2, alpha subunit, C-terminal

PFAM

PF00575
PF07541

PRINTS

PIRSF

SMART

SM00316

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite