InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SFXN1

Summary

InnateDB Protein

IDBP-58421.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFXN1

Protein Name

sideroflexin 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000316905

InnateDB Gene

IDBG-58419 (SFXN1)

Protein Structure

UniProt Annotation

Function

Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.

Subcellular Localization

Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008324	cation transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0006826	iron ion transport
GO:0030218	erythrocyte differentiation
GO:0055072	iron ion homeostasis
GO:0055085	transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004686 Tricarboxylate/iron carrier

PFAM

PF03820

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H9B4

PhosphoSite

PhosphoSite-Q9H9B4

TrEMBL

D6RFI0

UniProt Splice Variant

Entrez Gene

94081

UniGene

Hs.732081

RefSeq

NP_073591

HUGO

HGNC:16085

OMIM

615569

CCDS

CCDS4394

HPRD

18044

IMGT

EMBL

AC091393 AF327346 AK022287 AK022938 AK056915 BC020517 BC063241 BX648188 CH471062

GenPept

AAH20517 AAH63241 AAL56007 BAB14003 BAB14318 BAG51825 EAW61370 EAW61372 EAW61374 EAW61375