InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTDP1

Summary

InnateDB Protein

IDBP-5552.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTDP1

Protein Name

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

Synonyms

CCFDN; FCP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000075430

InnateDB Gene

IDBG-5548 (CTDP1)

Protein Structure

UniProt Annotation

Function

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269PubMed:22692537}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:22692537}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:22692537}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:22692537}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:22692537}. Midbody {ECO:0000269PubMed:22692537}. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively.

Disease Associations

Congenital cataracts, facial dysmorphism, and neuropathy (CCFDN) [MIM:604168]: An autosomal recessive developmental disorder characterized by a complex clinical phenotype with seemingly unrelated features involving multiple organs and systems. Developmental abnormalities include congenital cataracts and microcorneae, hypomyelination of the peripheral nervous system, impaired physical growth, delayed early motor and intellectual development, facial dysmorphism and hypogonadism. Central nervous system involvement, with cerebral and spinal cord atrophy, may be the result of disrupted development with superimposed degenerative changes. Affected individuals are prone to severe rhabdomyolysis after viral infections and to serious complications related to general anesthesia (such as pulmonary edema and epileptic seizures). {ECO:0000269PubMed:14517542}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:9765293}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.

Experimentally validated
Total	59 [view]
Protein-Protein	58 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003899	DNA-directed RNA polymerase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0008420	CTD phosphatase activity

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006470	protein dephosphorylation
GO:0010458	exit from mitosis
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0015629	actin cytoskeleton
GO:0030496	midbody
GO:0051233	spindle midzone

Protein Structure and Domains

PDB ID

InterPro

IPR001357 BRCT domain
IPR004274 NLI interacting factor
IPR011053 Single hybrid motif
IPR011947 FCP1-like phosphatase, phosphatase domain
IPR015388 FCP1-like phosphatase, C-terminal
IPR023214 HAD-like domain

PFAM