InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bid

Summary

InnateDB Protein

IDBP-534869.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bid

Protein Name

BH3 interacting domain death agonist

Synonyms

2700049M22Rik; AI875481; AU022477;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125731

InnateDB Gene

IDBG-184076 (Bid)

Protein Structure

UniProt Annotation

Function

Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c. {ECO:0000269PubMed:9873064}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9873064}. Mitochondrion membrane {ECO:0000269PubMed:9873064}. Note=When uncleaved, it is predominantly cytoplasmic. p15 BID translocates to mitochondria as an integral membrane protein. p13 and p22 BID are associated with the mitochondrial membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006626	protein targeting to mitochondrion
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007420	brain development
GO:0008637	apoptotic mitochondrial changes
GO:0032355	response to estradiol
GO:0032459	regulation of protein oligomerization
GO:0032464	positive regulation of protein homooligomerization
GO:0034349	glial cell apoptotic process
GO:0042127	regulation of cell proliferation
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051260	protein homooligomerization
GO:0090150	establishment of protein localization to membrane
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097191	extrinsic apoptotic signaling pathway
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:2000045	regulation of G1/S transition of mitotic cell cycle
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway