Version 5.4
Mus musculus Protein: Th
Summary
InnateDB Protein IDBP-533617.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Th
Protein Name tyrosine hydroxylase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000115434
InnateDB Gene IDBG-212648 (Th)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004511 tyrosine 3-monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0001963 synaptic transmission, dopaminergic
GO:0006585 dopamine biosynthetic process from tyrosine
GO:0007507 heart development
GO:0007612 learning
GO:0007613 memory
GO:0007617 mating behavior
GO:0007626 locomotory behavior
GO:0008016 regulation of heart contraction
GO:0009887 organ morphogenesis
GO:0042755 eating behavior
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030424 axon
GO:0043005 neuron projection
GO:0043204 perikaryon
Protein Structure and Domains
PDB ID MGI:98735
InterPro IPR019774 Aromatic amino acid hydroxylase, C-terminal
IPR021164 Tyrosine hydroxylase, conserved site
PFAM PF00351
PF12549
PRINTS PR00372
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z0B1
UniProt Splice Variant
Entrez Gene 21823
UniGene Mm.1292
RefSeq
MGI ID
MGI Symbol Th
OMIM
CCDS
HPRD
IMGT
EMBL AC012382
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca