InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYN3

Summary

InnateDB Protein

IDBP-5204.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYN3

Protein Name

synapsin III

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351614

InnateDB Gene

IDBG-5198 (SYN3)

Protein Structure

UniProt Annotation

Function

May be involved in the regulation of neurotransmitter release and synaptogenesis.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.

Disease Associations

Tissue Specificity

Neuron specific. Detected predominantly in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0007269	neurotransmitter secretion
GO:0008152	metabolic process

Cellular Component

GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR001359 Synapsin
IPR013651 ATP-grasp fold, RimK-type
IPR016185 Pre-ATP-grasp domain
IPR019736 Synapsin, phosphorylation site
IPR020897 Synapsin, pre-ATP-grasp domain
IPR020898 Synapsin, ATP-binding domain

PFAM

PF08443
PF10581
PF02078
PF02750

PRINTS

PR01368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14994