Version 5.4
Homo sapiens Protein: SYN3
Summary
InnateDB Protein IDBP-5200.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYN3
Protein Name synapsin III
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000330219
InnateDB Gene IDBG-5198 (SYN3)
Protein Structure
UniProt Annotation
Function May be involved in the regulation of neurotransmitter release and synaptogenesis.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
Disease Associations
Tissue Specificity Neuron specific. Detected predominantly in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
Biological Process
GO:0007269 neurotransmitter secretion
GO:0008152 metabolic process
Cellular Component
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR001359 Synapsin
IPR020898 Synapsin, ATP-binding domain
PFAM PF02750
PRINTS PR01368
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14994
PhosphoSite PhosphoSite-O14994
TrEMBL
UniProt Splice Variant
Entrez Gene 8224
UniGene Hs.666490
RefSeq
HUGO HGNC:11496
OMIM 602705
CCDS
HPRD 04083
IMGT
EMBL AF046873 BC075065 BC075066 BC143874 CH471095 CR456589 Z71183 Z80902 Z82181 Z82246 Z83846 Z98256
GenPept AAC15101 AAH75065 AAH75066 AAI43875 CAB10915 CAB62947 CAB63144 CAG30475 CAI18771 CAI18775 CAI18794 EAW60034

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca