InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERI1

Summary

InnateDB Protein

IDBP-482718.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERI1

Protein Name

exoribonuclease 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000429615

InnateDB Gene

IDBG-6871 (ERI1)

Protein Structure

UniProt Annotation

Function

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. {ECO:0000269PubMed:14536070, ECO:0000269PubMed:16912046}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16912046}. Nucleus {ECO:0000269PubMed:16912046}. Nucleus, nucleolus {ECO:0000269PubMed:16912046}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0008408	3'-5' exonuclease activity
GO:0019843	rRNA binding
GO:0043022	ribosome binding
GO:0046872	metal ion binding
GO:0071207	histone pre-mRNA stem-loop binding