InnateDB Protein
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IDBP-481143.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GRSF1
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Protein Name
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G-rich RNA sequence binding factor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000425430
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InnateDB Gene
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IDBG-22735 (GRSF1)
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Protein Structure
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Function |
Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. {ECO:0000269PubMed:23473033, ECO:0000269PubMed:23473034}.
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Subcellular Localization |
Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Note=Forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
50
[view]
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Protein-Protein |
50
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q12849
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PhosphoSite |
PhosphoSite-Q12849
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TrEMBL |
A0A024RD99
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UniProt Splice Variant |
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Entrez Gene |
2926
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UniGene |
Hs.709934
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RefSeq |
NP_001091947
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HUGO |
HGNC:4610
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OMIM |
604851
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CCDS |
CCDS47070
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HPRD |
07276
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IMGT |
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EMBL |
AC021989
AK056891
AK090755
AK094806
AK095799
AK097055
AK127161
BC040485
CH471057
U07231
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GenPept |
AAC95399
AAH40485
AAY40942
BAC03513
BAC86863
BAG51822
BAG52934
BAG53131
BAG53414
EAX05631
EAX05632
EAX05633
EAX05634
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