InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIO

Summary

InnateDB Protein

IDBP-478908.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIO

Protein Name

triple functional domain (PTPRF interacting)

Synonyms

ARHGEF23; tgat;

Species

Homo sapiens

Ensembl Protein

ENSP00000426342

InnateDB Gene

IDBG-12835 (TRIO)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002017 Spectrin repeat
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR016184 Capsid/spike protein, ssDNA virus
IPR018159 Spectrin/alpha-actinin

PFAM

PF00621
PF00018
PF14604
PF00169
PF00435
PF07679

PRINTS

PR00452

PIRSF

SMART

SM00325
SM00326
SM00233
SM00408
SM00409
SM00150

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt