InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF2S1

Summary

InnateDB Protein

IDBP-478315.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2S1

Protein Name

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Synonyms

EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A;

Species

Homo sapiens

Ensembl Protein

ENSP00000425299

InnateDB Gene

IDBG-9859 (EIF2S1)

Protein Structure

UniProt Annotation

Function

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Subcellular Localization

Cytoplasmic granule {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	59 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0043022	ribosome binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0006413	translational initiation
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0010467	gene expression
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005829	cytosol
GO:0005844	polysome
GO:0005850	eukaryotic translation initiation factor 2 complex
GO:0005851	eukaryotic translation initiation factor 2B complex
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003029 Ribosomal protein S1, RNA-binding domain
IPR011488 Translation initiation factor 2, alpha subunit
IPR012340 Nucleic acid-binding, OB-fold
IPR022967 RNA-binding domain, S1
IPR024054 Translation initiation factor 2, alpha subunit, middle domain
IPR024055 Translation initiation factor 2, alpha subunit, C-terminal

PFAM

PF00575
PF07541

PRINTS

PIRSF

SMART

SM00316

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05198