Version 5.4
Homo sapiens Protein: GABRG3
Summary
InnateDB Protein IDBP-4420.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRG3
Protein Name gamma-aminobutyric acid (GABA) A receptor, gamma 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000331912
InnateDB Gene IDBG-4418 (GABRG3)
Protein Structure
UniProt Annotation
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005230 extracellular ligand-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
IPR005440 Gamma-aminobutyric-acid A receptor, gamma 3 subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
PFAM PF02932
PF02931
PRINTS PR01620
PR01623
PR00253
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99928
PhosphoSite PhosphoSite-Q99928
TrEMBL
UniProt Splice Variant
Entrez Gene 2567
UniGene Hs.740015
RefSeq
HUGO HGNC:4088
OMIM 600233
CCDS
HPRD 02579
IMGT
EMBL AC104002 AC127511 AC135326 AC136896 AC144833 AC145436 AF269135 AF269136 AF269137 AF269138 AF269139 AF269140 AF269141 AF269142 AF269143 AF269144 AH009226 BC045709 CH471151 EU606049 S82769
GenPept AAB39369 AAF63215 AAF99698 EAW57658

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca