InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptger4

Summary

InnateDB Protein

IDBP-401776.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptger4

Protein Name

prostaglandin E receptor 4 (subtype EP4)

Synonyms

EP4; Ptgerep4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112858

InnateDB Gene

IDBG-128023 (Ptger4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004957	prostaglandin E receptor activity

Biological Process

GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007254	JNK cascade
GO:0009612	response to mechanical stimulus
GO:0030278	regulation of ossification
GO:0032496	response to lipopolysaccharide
GO:0033624	negative regulation of integrin activation
GO:0050728	negative regulation of inflammatory response
GO:0060348	bone development
GO:0070371	ERK1 and ERK2 cascade
GO:2000420	negative regulation of eosinophil extravasation

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:104311

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001105 Thromboxane receptor
IPR001244 Prostaglandin DP receptor
IPR001758 Prostanoid EP4 receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00429
PR00428
PR00586
PR01788

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite