InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDC3

Summary

InnateDB Protein

IDBP-377750.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDC3

Protein Name

enhancer of mRNA decapping 3 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000401343

InnateDB Gene

IDBG-22430 (EDC3)

Protein Structure

UniProt Annotation

Function

Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269PubMed:16364915, ECO:0000269PubMed:17533573, ECO:0000269PubMed:18678652}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:16364915}. Note=Processing bodies (PB).

Disease Associations

Tissue Specificity

Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland. {ECO:0000269PubMed:17533573}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay