InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOP2B

Summary

InnateDB Protein

IDBP-368142.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOP2B

Protein Name

topoisomerase (DNA) II beta 180kDa

Synonyms

top2beta; TOPIIB;

Species

Homo sapiens

Ensembl Protein

ENSP00000396704

InnateDB Gene

IDBG-22611 (TOP2B)

Protein Structure

UniProt Annotation

Function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. {ECO:0000269PubMed:10684600, ECO:0000269PubMed:12837248}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	59 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008301	DNA binding, bending
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0000819	sister chromatid segregation
GO:0001764	neuron migration
GO:0006200	ATP catabolic process
GO:0006265	DNA topological change
GO:0006268	DNA unwinding involved in DNA replication
GO:0006312	mitotic recombination
GO:0007409	axonogenesis
GO:0030900	forebrain development
GO:0044774	mitotic DNA integrity checkpoint

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)

Protein Structure and Domains

PDB ID

InterPro

IPR001154 DNA topoisomerase II, eukaryotic-type
IPR001241 DNA topoisomerase, type IIA
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR012542 DTHCT
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
IPR013760 DNA topoisomerase, type IIA-like domain
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF00521
PF02518
PF13581
PF08070
PF00204

PRINTS

PR01158
PR00418

PIRSF

SMART

SM00433
SM00434
SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt