Homo sapiens Protein: RAD51 | |||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||
InnateDB Protein | IDBP-366349.4 | ||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
Gene Symbol | RAD51 | ||||||||||||||||||||||||||||||||||||
Protein Name | RAD51 homolog (S. cerevisiae) | ||||||||||||||||||||||||||||||||||||
Synonyms | BRCC5; HRAD51; HsRad51; HsT16930; MRMV2; RAD51A; RECA; | ||||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000406602 | ||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-6509 (RAD51) | ||||||||||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||||||||||
Function | Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2- scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. {ECO:0000269PubMed:12205100, ECO:0000269PubMed:12442171, ECO:0000269PubMed:18417535, ECO:0000269PubMed:20231364, ECO:0000269PubMed:20348101, ECO:0000269PubMed:20413593, ECO:0000269PubMed:23509288, ECO:0000269PubMed:23754376}. | ||||||||||||||||||||||||||||||||||||
Subcellular Localization | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner. | ||||||||||||||||||||||||||||||||||||
Disease Associations | Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269PubMed:10807537}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Mirror movements 2 (MRMV2) [MIM:614508]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. {ECO:0000269PubMed:22305526}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||||||||||||||||
Tissue Specificity | Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast. | ||||||||||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||||||||||
InterPro |
IPR010995
DNA repair Rad51/transcription factor NusA, alpha-helical IPR013632 DNA recombination and repair protein Rad51, C-terminal IPR013765 DNA recombination and repair protein RecA IPR014774 Circadian clock protein KaiC/DNA repair protein RadA IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF08423
PF00154 PF06745 |
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PRINTS |
PR00142
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PIRSF | |||||||||||||||||||||||||||||||||||||
SMART | |||||||||||||||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||||||
SwissProt | Q06609 | ||||||||||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q06609 | ||||||||||||||||||||||||||||||||||||
TrEMBL | Q9NZG9 | ||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
Entrez Gene | 5888 | ||||||||||||||||||||||||||||||||||||
UniGene | Hs.607865 | ||||||||||||||||||||||||||||||||||||
RefSeq | NP_001157742 | ||||||||||||||||||||||||||||||||||||
HUGO | HGNC:9817 | ||||||||||||||||||||||||||||||||||||
OMIM | 179617 | ||||||||||||||||||||||||||||||||||||
CCDS | CCDS53932 | ||||||||||||||||||||||||||||||||||||
HPRD | 01557 | ||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||
EMBL | AC012476 AC022405 AF165088 AF165089 AF165090 AF165091 AF165092 AF165093 AF165094 AF203691 AF233740 AF233741 AF233742 AF233743 AF233744 AF236021 AK131299 AK291969 AK313503 AY196785 BC001459 CH471125 CR536559 D13804 D14134 EU362635 | ||||||||||||||||||||||||||||||||||||
GenPept | AAD49705 AAF61901 AAF69145 AAH01459 AAN87149 ABY59731 BAA02962 BAA03189 BAD18467 BAF84658 BAG36283 CAG38796 EAW92432 EAW92434 EAW92435 | ||||||||||||||||||||||||||||||||||||