InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYNJ1

Summary

InnateDB Protein

IDBP-362340.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYNJ1

Protein Name

synaptojanin 1

Synonyms

INPP5G; PARK20;

Species

Homo sapiens

Ensembl Protein

ENSP00000409667

InnateDB Gene

IDBG-1770 (SYNJ1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity
GO:0042578	phosphoric ester hydrolase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006796	phosphate-containing compound metabolic process
GO:0006836	neurotransmitter transport
GO:0007612	learning
GO:0008219	cell death
GO:0016082	synaptic vesicle priming
GO:0016191	synaptic vesicle uncoating
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046488	phosphatidylinositol metabolic process
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation
GO:0048488	synaptic vesicle endocytosis
GO:0048489	synaptic vesicle transport

Cellular Component

GO:0005829	cytosol
GO:0030117	membrane coat

Protein Structure and Domains

PDB ID

InterPro

IPR000300 Inositol polyphosphate-related phosphatase
IPR000504 RNA recognition motif domain
IPR002013 Synaptojanin, N-terminal
IPR005135 Endonuclease/exonuclease/phosphatase
IPR015047 Domain of unknown function DUF1866

PFAM

PF00076
PF02383
PF03372
PF14529
PF08952

PRINTS

PIRSF

SMART

SM00128
SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite