InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMGN1

Summary

InnateDB Protein

IDBP-3518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGN1

Protein Name

high mobility group nucleosome binding domain 1

Synonyms

HMG14;

Species

Homo sapiens

Ensembl Protein

ENSP00000370125

InnateDB Gene

IDBG-3514 (HMGN1)

Protein Structure

UniProt Annotation

Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006325	chromatin organization
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010224	response to UV-B
GO:0010225	response to UV-C
GO:0032786	positive regulation of DNA-templated transcription, elongation
GO:0040034	regulation of development, heterochronic
GO:0048597	post-embryonic camera-type eye morphogenesis
GO:0050678	regulation of epithelial cell proliferation