InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHAF1B

Summary

InnateDB Protein

IDBP-2979.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHAF1B

Protein Name

chromatin assembly factor 1, subunit B (p60)

Synonyms

CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7;

Species

Homo sapiens

Ensembl Protein

ENSP00000315700

InnateDB Gene

IDBG-2977 (CHAF1B)

Protein Structure

UniProt Annotation

Function

Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269PubMed:9813080}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9614144}. Cytoplasm {ECO:0000269PubMed:9614144}. Note=DNA replication foci. Cytoplasmic in M phase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0042393	histone binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006335	DNA replication-dependent nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0007049	cell cycle
GO:0031497	chromatin assembly