InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNRF3

Summary

InnateDB Protein

IDBP-294771.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNRF3

Protein Name

zinc and ring finger 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384456

InnateDB Gene

IDBG-3438 (ZNRF3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269PubMed:22575959}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22575959}; Single-pass type I membrane protein {ECO:0000269PubMed:22575959}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0038018	Wnt receptor catabolic process
GO:0072089	stem cell proliferation
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000051	negative regulation of non-canonical Wnt signaling pathway