InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNRC6B

Summary

InnateDB Protein

IDBP-293363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNRC6B

Protein Name

trinucleotide repeat containing 6B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384795

InnateDB Gene

IDBG-8635 (TNRC6B)

Protein Structure

UniProt Annotation

Function

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269PubMed:16289642, ECO:0000269PubMed:19167051, ECO:0000269PubMed:19304925, ECO:0000269PubMed:21981923}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:16289642, ECO:0000269PubMed:19167051}. Note=Mammalian P-bodies are also known as GW bodies (GWBs).

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006417	regulation of translation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0031047	gene silencing by RNA
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay