InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPIL2

Summary

InnateDB Protein

IDBP-292705.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPIL2

Protein Name

peptidylprolyl isomerase (cyclophilin)-like 2

Synonyms

CYC4; Cyp-60; CYP60; hCyP-60; UBOX7;

Species

Homo sapiens

Ensembl Protein

ENSP00000384299

InnateDB Gene

IDBG-2106 (PPIL2)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	13 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0034450	ubiquitin-ubiquitin ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0007596	blood coagulation
GO:0016567	protein ubiquitination
GO:0050900	leukocyte migration

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005796	Golgi lumen

Protein Structure and Domains

PDB ID

InterPro

IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR003613 U box domain
IPR027799 Replication termination factor 2, RING-finger
IPR029000 Cyclophilin-like domain

PFAM

PF00160
PF04564
PF04641

PRINTS

PR00153

PIRSF

SMART

SM00504

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt