InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stk11

Summary

InnateDB Protein

IDBP-271021.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Stk11

Protein Name

serine/threonine kinase 11

Synonyms

AA408040; Lkb1; Par-4; R75140;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101009

InnateDB Gene

IDBG-172765 (Stk11)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0002039	p53 binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030295	protein kinase activator activity
GO:0032403	protein complex binding

Biological Process

GO:0001894	tissue homeostasis
GO:0006468	protein phosphorylation
GO:0007050	cell cycle arrest
GO:0007409	axonogenesis
GO:0030111	regulation of Wnt signaling pathway
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147	activation of protein kinase activity
GO:0033762	response to glucagon
GO:0033993	response to lipid
GO:0036399	TCR signalosome assembly
GO:0043276	anoikis
GO:0045059	positive thymic T cell selection
GO:0045722	positive regulation of gluconeogenesis
GO:0046777	protein autophosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050772	positive regulation of axonogenesis
GO:0050852	T cell receptor signaling pathway
GO:0051291	protein heterooligomerization
GO:0051645	Golgi localization
GO:0051896	regulation of protein kinase B signaling
GO:0060070	canonical Wnt signaling pathway
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0036398	TCR signalosome

Protein Structure and Domains

PDB ID

MGI:1341870

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt