Mus musculus Protein: Atf4
Summary
InnateDB Protein IDBP-262036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atf4
Protein Name activating transcription factor 4
Synonyms Atf-4; C/ATF; CREB2; TAXREB67;
Species Mus musculus
Ensembl Protein ENSMUSP00000105234
InnateDB Gene IDBG-163574 (Atf4)
Protein Structure
UniProt Annotation
Function Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000269PubMed:15775988, ECO:0000269PubMed:21159964, ECO:0000269PubMed:21768648, ECO:0000269PubMed:22298775, ECO:0000269PubMed:22572884, ECO:0000269PubMed:23663782, ECO:0000269PubMed:8506317}.
Subcellular Localization Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Colocalizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 66 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006094 gluconeogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034976 response to endoplasmic reticulum stress
GO:0043267 negative regulation of potassium ion transport
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0032590 dendrite membrane
Protein Structure and Domains
PDB ID MGI:88096
InterPro IPR004827 Basic-leucine zipper domain
PFAM PF00170
PF07716
PRINTS
PIRSF
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q06507
PhosphoSite PhosphoSite-Q06507
TrEMBL Q794G7
UniProt Splice Variant
Entrez Gene 11911
UniGene Mm.641
RefSeq NP_033846
MGI ID
MGI Symbol Atf4
OMIM
CCDS CCDS37145
HPRD
IMGT
EMBL AB012277 AK138657 AK144777 AK146193 AK156298 AK157839 BC085169 CH466550 L13791 M94087
GenPept AAA40476 AAA53043 AAH85169 BAA25314 BAE23736 BAE26060 BAE26967 BAE33662 BAE34220 EDL04604 EDL04605