InnateDB Protein
|
IDBP-262036.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Atf4
|
Protein Name
|
activating transcription factor 4
|
Synonyms
|
Atf-4; C/ATF; CREB2; TAXREB67;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000105234
|
InnateDB Gene
|
IDBG-163574 (Atf4)
|
Protein Structure
|
|
Function |
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000269PubMed:15775988, ECO:0000269PubMed:21159964, ECO:0000269PubMed:21768648, ECO:0000269PubMed:22298775, ECO:0000269PubMed:22572884, ECO:0000269PubMed:23663782, ECO:0000269PubMed:8506317}.
|
Subcellular Localization |
Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Colocalizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
|
Protein-Protein |
23
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
66 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000978
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding
|
GO:0001077
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0003677
|
DNA binding
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0005515
|
protein binding
|
GO:0008022
|
protein C-terminus binding
|
GO:0043565
|
sequence-specific DNA binding
|
|
Biological Process |
GO:0006094
|
gluconeogenesis
|
GO:0006351
|
transcription, DNA-templated
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0006357
|
regulation of transcription from RNA polymerase II promoter
|
GO:0007214
|
gamma-aminobutyric acid signaling pathway
|
GO:0034976
|
response to endoplasmic reticulum stress
|
GO:0043267
|
negative regulation of potassium ion transport
|
GO:0043525
|
positive regulation of neuron apoptotic process
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0045893
|
positive regulation of transcription, DNA-templated
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
GO:0070059
|
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
|
Cellular Component |
|
PDB ID |
MGI:88096
|
InterPro |
IPR004827
Basic-leucine zipper domain
|
PFAM |
PF00170
PF07716
|
PRINTS |
|
PIRSF |
|
SMART |
SM00338
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q06507
|
PhosphoSite |
PhosphoSite-Q06507
|
TrEMBL |
Q794G7
|
UniProt Splice Variant |
|
Entrez Gene |
11911
|
UniGene |
Mm.641
|
RefSeq |
NP_033846
|
MGI ID |
|
MGI Symbol |
Atf4
|
OMIM |
|
CCDS |
CCDS37145
|
HPRD |
|
IMGT |
|
EMBL |
AB012277
AK138657
AK144777
AK146193
AK156298
AK157839
BC085169
CH466550
L13791
M94087
|
GenPept |
AAA40476
AAA53043
AAH85169
BAA25314
BAE23736
BAE26060
BAE26967
BAE33662
BAE34220
EDL04604
EDL04605
|
|
|