InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACAA1

Summary

InnateDB Protein

IDBP-25583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACAA1

Protein Name

acetyl-CoA acyltransferase 1

Synonyms

ACAA; PTHIO; THIO;

Species

Homo sapiens

Ensembl Protein

ENSP00000333664

InnateDB Gene

IDBG-25581 (ACAA1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Peroxisome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003988	acetyl-CoA C-acyltransferase activity
GO:0005515	protein binding
GO:0016401	palmitoyl-CoA oxidase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0008610	lipid biosynthetic process
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559	unsaturated fatty acid metabolic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response

Cellular Component

GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR002155 Thiolase
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR016039 Thiolase-like
IPR020616 Thiolase, N-terminal
IPR020617 Thiolase, C-terminal

PFAM

PF08541
PF00108
PF02803

PRINTS

PIRSF

PIRSF000429

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P09110