Homo sapiens Protein: ATF4
Summary
InnateDB Protein IDBP-236990.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATF4
Protein Name activating transcription factor 4 (tax-responsive enhancer element B67)
Synonyms CREB-2; CREB2; TAXREB67; TXREB;
Species Homo sapiens
Ensembl Protein ENSP00000379912
InnateDB Gene IDBG-8409 (ATF4)
Protein Structure
UniProt Annotation
Function Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000250, ECO:0000269PubMed:15775988, ECO:0000269PubMed:16682973, ECO:0000269PubMed:18940792}.
Subcellular Localization Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 111 [view]
Protein-Protein 101 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006094 gluconeogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006520 cellular amino acid metabolic process
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032922 circadian regulation of gene expression
GO:0034976 response to endoplasmic reticulum stress
GO:0043525 positive regulation of neuron apoptotic process
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
Protein Structure and Domains
PDB ID
InterPro IPR004827 Basic-leucine zipper domain
PFAM PF00170
PF07716
PRINTS
PIRSF
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P18848
PhosphoSite PhosphoSite-P18848
TrEMBL Q96AQ3
UniProt Splice Variant
Entrez Gene 468
UniGene Hs.634673
RefSeq NP_877962
HUGO HGNC:786
OMIM 604064
CCDS CCDS13996
HPRD 06817
IMGT
EMBL AK296028 AL022312 BC008090 BC011994 BC016855 BC022088 BC024775 BC044895 BC073754 BC073990 CH471095 CR456384 D90209 M86842
GenPept AAA52071 AAH08090 AAH11994 AAH16855 AAH22088 AAH24775 AAH44895 AAH73754 AAH73990 BAA14234 BAG58796 CAB45284 CAG30270 EAW60341 EAW60342