InnateDB Protein
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IDBP-236990.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATF4
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Protein Name
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activating transcription factor 4 (tax-responsive enhancer element B67)
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Synonyms
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CREB-2; CREB2; TAXREB67; TXREB;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379912
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InnateDB Gene
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IDBG-8409 (ATF4)
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Protein Structure
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Function |
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000250, ECO:0000269PubMed:15775988, ECO:0000269PubMed:16682973, ECO:0000269PubMed:18940792}.
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Subcellular Localization |
Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
111
[view]
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Protein-Protein |
101
[view]
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Protein-DNA |
10
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
GO:0006094
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gluconeogenesis
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006520
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cellular amino acid metabolic process
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GO:0006987
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activation of signaling protein activity involved in unfolded protein response
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GO:0030968
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endoplasmic reticulum unfolded protein response
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GO:0032922
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circadian regulation of gene expression
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GO:0034976
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response to endoplasmic reticulum stress
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GO:0043525
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positive regulation of neuron apoptotic process
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GO:0044267
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cellular protein metabolic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0070059
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intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
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Cellular Component |
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PDB ID |
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InterPro |
IPR004827
Basic-leucine zipper domain
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PFAM |
PF00170
PF07716
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PRINTS |
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PIRSF |
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SMART |
SM00338
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TIGRFAMs |
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Modification |
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SwissProt |
P18848
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PhosphoSite |
PhosphoSite-P18848
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TrEMBL |
Q96AQ3
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UniProt Splice Variant |
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Entrez Gene |
468
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UniGene |
Hs.634673
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RefSeq |
NP_877962
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HUGO |
HGNC:786
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OMIM |
604064
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CCDS |
CCDS13996
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HPRD |
06817
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IMGT |
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EMBL |
AK296028
AL022312
BC008090
BC011994
BC016855
BC022088
BC024775
BC044895
BC073754
BC073990
CH471095
CR456384
D90209
M86842
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GenPept |
AAA52071
AAH08090
AAH11994
AAH16855
AAH22088
AAH24775
AAH44895
AAH73754
AAH73990
BAA14234
BAG58796
CAB45284
CAG30270
EAW60341
EAW60342
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