Version 5.4
Homo sapiens Protein: NGDN
Summary
InnateDB Protein IDBP-235965.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NGDN
Protein Name neuroguidin, EIF4E binding protein
Synonyms C14orf120; CANu1; LCP5; lpd-2; NGD;
Species Homo sapiens
Ensembl Protein ENSP00000380340
InnateDB Gene IDBG-3334 (NGDN)
Protein Structure
UniProt Annotation
Function Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000269PubMed:18547334}. Chromosome, centromere {ECO:0000269PubMed:18547334}. Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006417 regulation of translation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
Protein Structure and Domains
PDB ID
InterPro IPR007146 Sas10/Utp3/C1D
PFAM PF04000
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEJ9
PhosphoSite PhosphoSite-Q8NEJ9
TrEMBL G3V4G1
UniProt Splice Variant
Entrez Gene 25983
UniGene Hs.630479
RefSeq NP_056329
HUGO HGNC:20271
OMIM 610777
CCDS CCDS32051
HPRD
IMGT
EMBL AK291875 AL050003 AL132855 BC030817 CH471078
GenPept AAH30817 BAF84564 CAB43232 EAW66149

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca