InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRMP1

Summary

InnateDB Protein

IDBP-234327.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRMP1

Protein Name

collapsin response mediator protein 1

Synonyms

CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3;

Species

Homo sapiens

Ensembl Protein

ENSP00000380987

InnateDB Gene

IDBG-8805 (CRMP1)

Protein Structure

UniProt Annotation

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. {ECO:0000269PubMed:11562390, ECO:0000269PubMed:19799413}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11562390}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:11562390}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:11562390}. Note=Associated with centrosomes and the mitotic spindle during metaphase.

Disease Associations

Tissue Specificity

Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	104 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006208	pyrimidine nucleobase catabolic process
GO:0007399	nervous system development
GO:0007411	axon guidance