Version 5.4
Homo sapiens Protein: CA8
Summary
InnateDB Protein IDBP-22859.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CA8
Protein Name carbonic anhydrase VIII
Synonyms CA-VIII; CALS; CAMRQ3; CARP;
Species Homo sapiens
Ensembl Protein ENSP00000314407
InnateDB Gene IDBG-22857 (CA8)
Protein Structure
UniProt Annotation
Function Does not have a carbonic anhydrase catalytic activity.
Subcellular Localization
Disease Associations Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3) [MIM:613227]: A congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mental retardation. {ECO:0000269PubMed:19461874}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001148 Alpha carbonic anhydrase
PFAM PF00194
PRINTS
PIRSF
SMART SM01057
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35219
PhosphoSite PhosphoSite-P35219
TrEMBL B4DFA0
UniProt Splice Variant
Entrez Gene 767
UniGene Hs.676224
RefSeq NP_004047
HUGO HGNC:1382
OMIM 114815
CCDS CCDS6174
HPRD 00266
IMGT
EMBL AK090655 AK289470 AK293999 AK314538 AY075022 BC069744 BC069794 BC108929 CH471068 L04656
GenPept AAA35653 AAH69744 AAH69794 AAI08930 AAL78170 BAF82159 BAG37128 BAG52209 BAG57361 EAW86826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca