InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R13B

Summary

InnateDB Protein

IDBP-22175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R13B

Protein Name

protein phosphatase 1, regulatory subunit 13B

Synonyms

ASPP1; p53BP2-like; p85;

Species

Homo sapiens

Ensembl Protein

ENSP00000202556

InnateDB Gene

IDBG-22173 (PPP1R13B)

Protein Structure

UniProt Annotation

Function

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269PubMed:11684014}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11684014}. Nucleus {ECO:0000269PubMed:11684014}. Note=Predominantly cytoplasmic. Some fraction is nuclear.

Disease Associations

Tissue Specificity

Reduced expression in breast carcinomas expressing a wild-type TP53 protein. {ECO:0000269PubMed:11684014}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	28 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0006915	apoptotic process
GO:0045786	negative regulation of cell cycle
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR002110 Ankyrin repeat
IPR011511 Variant SH3 domain
IPR020683 Ankyrin repeat-containing domain
IPR029071 Ubiquitin-related domain

PFAM