Version 5.4
Homo sapiens Protein: TH
Summary
InnateDB Protein IDBP-21715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TH
Protein Name tyrosine hydroxylase
Synonyms DYT14; DYT5b; TYH;
Species Homo sapiens
Ensembl Protein ENSP00000328814
InnateDB Gene IDBG-21705 (TH)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004511 tyrosine 3-monooxygenase activity
GO:0005515 protein binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0001666 response to hypoxia
GO:0001963 synaptic transmission, dopaminergic
GO:0003007 heart morphogenesis
GO:0006585 dopamine biosynthetic process from tyrosine
GO:0007507 heart development
GO:0007601 visual perception
GO:0007612 learning
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0008016 regulation of heart contraction
GO:0009653 anatomical structure morphogenesis
GO:0009887 organ morphogenesis
GO:0034641 cellular nitrogen compound metabolic process
GO:0042136 neurotransmitter biosynthetic process
GO:0042416 dopamine biosynthetic process
GO:0042418 epinephrine biosynthetic process
GO:0042421 norepinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
GO:0042462 eye photoreceptor cell development
GO:0043473 pigmentation
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0048596 embryonic camera-type eye morphogenesis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0033162 melanosome membrane
GO:0043005 neuron projection
GO:0043204 perikaryon
Protein Structure and Domains
PDB ID
InterPro IPR019774 Aromatic amino acid hydroxylase, C-terminal
IPR021164 Tyrosine hydroxylase, conserved site
PFAM PF00351
PF12549
PRINTS PR00372
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07101
PhosphoSite PhosphoSite-P07101
TrEMBL Q8IZE1
UniProt Splice Variant
Entrez Gene 7054
UniGene Hs.435609
RefSeq
HUGO HGNC:11782
OMIM 191290
CCDS
HPRD 01865
IMGT
EMBL AC132217 AY144495 AY211521 BC104967 BC143611 BC143614 CH471158 D00269 DQ677336 DQ677337 M17589 M20911 M20912 M23597 M24787 M24788 M24789 M24791 X05290 Y00414
GenPept AAA61167 AAA61168 AAA61170 AAA61171 AAA61173 AAA61179 AAA77650 AAI04968 AAI43612 AAI43615 AAN39539 AAP43671 ABG73364 ABG73365 BAA25097 CAA28908 CAA68472 EAX02493

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca