InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Th

Summary

InnateDB Protein

IDBP-212650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

tyrosine hydroxylase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000219

InnateDB Gene

IDBG-212648 (Th)

Protein Structure

UniProt Annotation

Function

Plays an important role in the physiology of adrenergic neurons.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004511	tyrosine 3-monooxygenase activity
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0008199	ferric iron binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0019904	protein domain specific binding
GO:0034617	tetrahydrobiopterin binding
GO:0035240	dopamine binding

Biological Process

GO:0001666	response to hypoxia
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0006585	dopamine biosynthetic process from tyrosine
GO:0006631	fatty acid metabolic process
GO:0006665	sphingolipid metabolic process
GO:0007507	heart development
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0007612	learning
GO:0007613	memory
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0009414	response to water deprivation
GO:0009416	response to light stimulus
GO:0009635	response to herbicide
GO:0009651	response to salt stress
GO:0009887	organ morphogenesis
GO:0010038	response to metal ion
GO:0010043	response to zinc ion
GO:0010259	multicellular organismal aging
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0015842	synaptic vesicle amine transport
GO:0016137	glycoside metabolic process
GO:0017085	response to insecticide
GO:0018963	phthalate metabolic process
GO:0021987	cerebral cortex development
GO:0031667	response to nutrient levels
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0033076	isoquinoline alkaloid metabolic process
GO:0035094	response to nicotine
GO:0035176	social behavior
GO:0035690	cellular response to drug
GO:0035902	response to immobilization stress
GO:0042136	neurotransmitter biosynthetic process
GO:0042214	terpene metabolic process
GO:0042416	dopamine biosynthetic process
GO:0042418	epinephrine biosynthetic process
GO:0042421	norepinephrine biosynthetic process
GO:0042423	catecholamine biosynthetic process
GO:0042462	eye photoreceptor cell development
GO:0042493	response to drug
GO:0042745	circadian sleep/wake cycle
GO:0042755	eating behavior
GO:0043434	response to peptide hormone
GO:0045471	response to ethanol
GO:0045472	response to ether
GO:0046684	response to pyrethroid
GO:0048545	response to steroid hormone
GO:0048596	embryonic camera-type eye morphogenesis
GO:0050890	cognition
GO:0051412	response to corticosterone
GO:0051602	response to electrical stimulus
GO:0052314	phytoalexin metabolic process
GO:0055114	oxidation-reduction process
GO:0070848	response to growth factor
GO:0071287	cellular response to manganese ion
GO:0071312	cellular response to alkaloid
GO:0071316	cellular response to nicotine
GO:0071333	cellular response to glucose stimulus
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005790	smooth endoplasmic reticulum
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0009898	cytoplasmic side of plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0033162	melanosome membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043204	perikaryon

Protein Structure and Domains

PDB ID

MGI:98735

InterPro

IPR005962 Tyrosine 3-monooxygenase
IPR019773 Tyrosine 3-monooxygenase-like
IPR019774 Aromatic amino acid hydroxylase, C-terminal
IPR021164 Tyrosine hydroxylase, conserved site

PFAM

PF00351
PF12549

PRINTS

PR00372

PIRSF

PIRSF000336

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt