InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hdac5

Summary

InnateDB Protein

IDBP-212522.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Hdac5

Protein Name

histone deacetylase 5

Synonyms

AI426555; Hdac4; mHDA1; mKIAA0600;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008999

InnateDB Gene

IDBG-212520 (Hdac5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 310 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	310 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002076	osteoblast development
GO:0007507	heart development
GO:0010832	negative regulation of myotube differentiation
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0033555	multicellular organismal response to stress
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0043393	regulation of protein binding
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048742	regulation of skeletal muscle fiber development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153	regulation of striated muscle cell differentiation
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016604	nuclear body
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1333784

InterPro

IPR000286 Histone deacetylase superfamily
IPR017320 Histone deacetylase class II, eukaryotic
IPR023801 Histone deacetylase domain
IPR024643 Histone deacetylase, glutamine rich N-terminal domain

PFAM

PF00850
PF12203

PRINTS

PR01270

PIRSF

PIRSF037911

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt