InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ric8

Summary

InnateDB Protein

IDBP-211868.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ric8

Protein Name

resistance to inhibitors of cholinesterase 8 homolog (C. elegans)

Synonyms

AI114950; RIC-8; Ric8a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026558

InnateDB Gene

IDBG-211866 (Ric8)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)- coupled receptor-mediated ERK activation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). Colocalizes with RIC8A in CA2 hippocampal neurons. {ECO:0000250, ECO:0000269PubMed:21158412}.

Disease Associations

Tissue Specificity

Expressed in neurons and neurites of the CA1 and CA2 subregions of the hippocampus (at protein level). In adult brain, it is expressed in the neocortex, hippocampus and cerebellum as well as in the pineal gland and ependymal layer. {ECO:0000269PubMed:12971991, ECO:0000269PubMed:21158412}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001944	vasculature development
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007369	gastrulation
GO:0008542	visual learning
GO:0009416	response to light stimulus
GO:0042074	cell migration involved in gastrulation
GO:0043087	regulation of GTPase activity
GO:0070586	cell-cell adhesion involved in gastrulation
GO:0071711	basement membrane organization