InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Odf3

Summary

InnateDB Protein

IDBP-211853.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Odf3

Protein Name

outer dense fiber of sperm tails 3

Synonyms

1700011O04Rik; SHIPPO1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026555

InnateDB Gene

IDBG-211851 (Odf3)

Protein Structure

UniProt Annotation

Function

Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11870087}. Note=Expressed in the cytoplasmic lobe of spermatids.

Disease Associations

Tissue Specificity

Testis-specific (at protein level). Expression restricted to the germ cell fraction, absent in somatic cell fractions such as Sertoli and Leydig cells. Expression detected in the third week postpartum (23 days) after haploid germ cells developed, expression increased with age. Expressed in the tails of elongated spermatids sticking out toward the tubular lumen, and in cytoplasmic droplets still attached to the spermatid tail membrane. Expressed in the tails of mature sperm, from the connecting piece proximal to the head, along the middle and principal pieces, down to the distal end piece. {ECO:0000269PubMed:11870087, ECO:0000269PubMed:16141072}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0008150	biological_process
GO:0030154	cell differentiation

Cellular Component

GO:0001520

outer dense fiber

Protein Structure and Domains

PDB ID

MGI:1916537

InterPro

IPR010736 Sperm-tail PG-rich repeat

PFAM

PF07004

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q920N1

PhosphoSite

PhosphoSite-Q920N1

TrEMBL

UniProt Splice Variant

Entrez Gene

69287

UniGene

Mm.56404

RefSeq

NP_081295

MGI ID

MGI Symbol

Odf3

OMIM

CCDS

CCDS40177

HPRD

IMGT

EMBL

AB067773 AK005883 BC104105 BC104106 BC106806

GenPept

AAI04106 AAI04107 AAI06807 BAB24298 BAB70733