Version 5.4
Mus musculus Protein: Scnn1b
Summary
InnateDB Protein IDBP-208765.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scnn1b
Protein Name sodium channel, nonvoltage-gated 1 beta
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000033161
InnateDB Gene IDBG-208763 (Scnn1b)
Protein Structure
UniProt Annotation
Function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subcellular Localization Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Apical membrane of epithelial cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Lung and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0015280 ligand-gated sodium channel activity
GO:0050699 WW domain binding
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0050891 multicellular organismal water homeostasis
GO:0050896 response to stimulus
GO:0050909 sensory perception of taste
GO:0055078 sodium ion homeostasis
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0034706 sodium channel complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:104696
InterPro IPR001873 Na+ channel, amiloride-sensitive
IPR004724 Epithelial sodium channel
PFAM PF00858
PRINTS PR01078
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WU38
PhosphoSite PhosphoSite-Q9WU38
TrEMBL A2RS45
UniProt Splice Variant
Entrez Gene 20277
UniGene Mm.7709
RefSeq NP_035455
MGI ID
MGI Symbol Scnn1b
OMIM
CCDS CCDS21804
HPRD
IMGT
EMBL AF112186 AK028909 AK036819 BC131969 BC132397 CH466531
GenPept AAD21245 AAI31970 AAI32398 BAC26190 BAC29591 EDL17253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca