InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLXIPL

Summary

InnateDB Protein

IDBP-20037.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLXIPL

Protein Name

MLX interacting protein-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343767

InnateDB Gene

IDBG-20029 (MLXIPL)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Note=WBSCR14 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Tissue Specificity

Expressed in liver, heart, kidney, cerebellum and intestinal tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0035538	carbohydrate response element binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0009653	anatomical structure morphogenesis
GO:0010255	glucose mediated signaling pathway
GO:0031325	positive regulation of cellular metabolic process
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0042304	regulation of fatty acid biosynthetic process
GO:0042593	glucose homeostasis
GO:0044281	small molecule metabolic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045821	positive regulation of glycolytic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046889	positive regulation of lipid biosynthetic process
GO:0055089	fatty acid homeostasis
GO:0070328	triglyceride homeostasis
GO:0071157	negative regulation of cell cycle arrest
GO:0090324	negative regulation of oxidative phosphorylation
GO:2000505	regulation of energy homeostasis