InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Etv6

Summary

InnateDB Protein

IDBP-193990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Etv6

Protein Name

ets variant gene 6 (TEL oncogene)

Synonyms

AW123102; AW557856; Tel;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079818

InnateDB Gene

IDBG-193988 (Etv6)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00237}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	8 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter