InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akap3

Summary

InnateDB Protein

IDBP-190309.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akap3

Protein Name

A kinase (PRKA) anchor protein 3

Synonyms

Prka3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093091

InnateDB Gene

IDBG-190307 (Akap3)

Protein Structure

UniProt Annotation

Function

May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269PubMed:11278869}. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006928	cellular component movement
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0008104	protein localization

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0031514	motile cilium
GO:0035686	sperm fibrous sheath
GO:0097228	sperm principal piece

Protein Structure and Domains

PDB ID

MGI:1341149

InterPro

IPR018292 A-kinase anchor 110kDa, C-terminal
IPR018459 RII binding domain
IPR020799 A-kinase anchor 110kDa

PFAM

PF05716
PF10522

PRINTS

PIRSF

SMART

SM00807

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88987

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

11642

UniGene

Mm.87748

RefSeq

NP_033780

MGI ID

MGI Symbol

Akap3

OMIM

CCDS

CCDS20558

HPRD

IMGT

EMBL

AF093406 BC100458 CH466523

GenPept

AAC63369 AAI00459 EDK99845