Version 5.4
Homo sapiens Protein: THAP7
Summary
InnateDB Protein IDBP-1878.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THAP7
Protein Name THAP domain containing 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000215742
InnateDB Gene IDBG-1876 (THAP7)
Protein Structure
UniProt Annotation
Function Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. {ECO:0000269PubMed:15561719}.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005694 chromosome
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR006612 Zinc finger, C2CH-type
PFAM PF05485
PRINTS
PIRSF
SMART SM00692
SM00980
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BT49
PhosphoSite PhosphoSite-Q9BT49
TrEMBL
UniProt Splice Variant
Entrez Gene 80764
UniGene Hs.512756
RefSeq NP_085050
HUGO HGNC:23190
OMIM 609518
CCDS CCDS13787
HPRD 15500
IMGT
EMBL AC002472 AK315457 BC004346 CH471176 CR456343
GenPept AAH04346 BAG37844 CAG30229 EAX02919 EAX02921

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca