InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppt1

Summary

InnateDB Protein

IDBP-184541.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppt1

Protein Name

palmitoyl-protein thioesterase 1

Synonyms

9530043G02Rik; AA960502; C77813; CLN1; D4Ertd184e; INCL; PPT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030412

InnateDB Gene

IDBG-184539 (Ppt1)

Protein Structure

UniProt Annotation

Function

Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Highest level in testis and kidney, lower in heart, brain and lung and lowest in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008474	palmitoyl-(protein) hydrolase activity
GO:0016290	palmitoyl-CoA hydrolase activity

Biological Process

GO:0002084	protein depalmitoylation
GO:0006309	apoptotic DNA fragmentation
GO:0006464	cellular protein modification process
GO:0006898	receptor-mediated endocytosis
GO:0006907	pinocytosis
GO:0007040	lysosome organization
GO:0007042	lysosomal lumen acidification
GO:0007269	neurotransmitter secretion
GO:0007399	nervous system development
GO:0007420	brain development
GO:0007601	visual perception
GO:0007625	grooming behavior
GO:0008306	associative learning
GO:0008344	adult locomotory behavior
GO:0015031	protein transport
GO:0016042	lipid catabolic process
GO:0030308	negative regulation of cell growth
GO:0031579	membrane raft organization
GO:0032429	regulation of phospholipase A2 activity
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0044257	cellular protein catabolic process
GO:0044265	cellular macromolecule catabolic process
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0048549	positive regulation of pinocytosis
GO:0051181	cofactor transport
GO:0051186	cofactor metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005764	lysosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045121	membrane raft
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome