InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZBTB7A

Summary

InnateDB Protein

IDBP-18261.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBTB7A

Protein Name

zinc finger and BTB domain containing 7A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323670

InnateDB Gene

IDBG-18259 (ZBTB7A)

Protein Structure

UniProt Annotation

Function

Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level). {ECO:0000269PubMed:15662416, ECO:0000269PubMed:9927193}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0035035	histone acetyltransferase binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated