InnateDB Protein
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IDBP-177459.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Grsf1
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Protein Name
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G-rich RNA sequence binding factor 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000077972
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InnateDB Gene
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IDBG-177457 (Grsf1)
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Protein Structure
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Function |
Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}. Note=Forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:106479
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C5Q4
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PhosphoSite |
PhosphoSite-Q8C5Q4
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TrEMBL |
Q8C298
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UniProt Splice Variant |
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Entrez Gene |
231413
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UniGene |
Mm.472981
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RefSeq |
NP_848815
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MGI ID |
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MGI Symbol |
Grsf1
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OMIM |
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CCDS |
CCDS19404
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HPRD |
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IMGT |
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EMBL |
AC121541
AC160533
AK044889
AK045986
AK077782
AK089014
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GenPept |
BAC32129
BAC32561
BAC37006
BAC40702
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