InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRD4

Summary

InnateDB Protein

IDBP-17521.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD4

Protein Name

dopamine receptor D4

Synonyms

D4DR;

Species

Homo sapiens

Ensembl Protein

ENSP00000176183

InnateDB Gene

IDBG-17519 (DRD4)

Protein Structure

UniProt Annotation

Function

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20100572}; Multi-pass membrane protein {ECO:0000269PubMed:20100572}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0015459	potassium channel regulator activity
GO:0017124	SH3 domain binding
GO:0035240	dopamine binding
GO:0042802	identical protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001662	behavioral fear response
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007614	short-term memory
GO:0007623	circadian rhythm
GO:0008306	associative learning
GO:0008344	adult locomotory behavior
GO:0008355	olfactory learning
GO:0009648	photoperiodism
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032417	positive regulation of sodium:proton antiporter activity
GO:0033674	positive regulation of kinase activity
GO:0034776	response to histamine
GO:0035176	social behavior
GO:0042053	regulation of dopamine metabolic process
GO:0042417	dopamine metabolic process
GO:0042596	fear response
GO:0042752	regulation of circadian rhythm
GO:0046928	regulation of neurotransmitter secretion
GO:0048148	behavioral response to cocaine
GO:0048149	behavioral response to ethanol
GO:0048545	response to steroid hormone
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0050804	regulation of synaptic transmission
GO:0050848	regulation of calcium-mediated signaling
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission
GO:0060041	retina development in camera-type eye
GO:0060080	regulation of inhibitory postsynaptic membrane potential
GO:0060406	positive regulation of penile erection
GO:1901386	negative regulation of voltage-gated calcium channel activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043197	dendritic spine
GO:0043679	axon terminus

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000929 Dopamine receptor family
IPR002185 Dopamine D4 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00242
PR00569

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21917