InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: M6PR

Summary

InnateDB Protein

IDBP-17513.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

M6PR

Protein Name

mannose-6-phosphate receptor (cation dependent)

Synonyms

CD-MPR; MPR 46; MPR-46; MPR46; SMPR;

Species

Homo sapiens

Ensembl Protein

ENSP00000000412

InnateDB Gene

IDBG-17511 (M6PR)

Protein Structure

UniProt Annotation

Function

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Subcellular Localization

Lysosome membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005537	mannose binding
GO:0015578	mannose transmembrane transporter activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0008333	endosome to lysosome transport
GO:0015761	mannose transport

Cellular Component

GO:0000323	lytic vacuole
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005770	late endosome
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane