InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itpr1

Summary

InnateDB Protein

IDBP-174304.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itpr1

Protein Name

inositol 1,4,5-trisphosphate receptor 1

Synonyms

D6Pas2; ENSMUSG00000072853; Gm10429; InsP3R; Ip3r; IP3R1; Itpr-1; opt; P400; Pcp-1; Pcp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032192

InnateDB Gene

IDBG-174302 (Itpr1)

Protein Structure

UniProt Annotation

Function

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. {ECO:0000269PubMed:19752026, ECO:0000269PubMed:20813840, ECO:0000269PubMed:2554142}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:2554142}; Multi-pass membrane protein {ECO:0000269PubMed:2554142}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005218	intracellular ligand-gated calcium channel activity
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001666	response to hypoxia
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0009791	post-embryonic development
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0048016	inositol phosphate-mediated signaling
GO:0050882	voluntary musculoskeletal movement
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055085	transmembrane transport
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005955	calcineurin complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031088	platelet dense granule membrane
GO:0031094	platelet dense tubular network
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:96623

InterPro

IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR000699 RIH (RyR and IP3R Homology) domain
IPR005821 Ion transport domain
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093 MIR motif

PFAM

PF01365
PF00520
PF08454
PF08709
PF02815

PRINTS

PR00779

PIRSF

SMART

SM00472

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt