InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Noa1

Summary

InnateDB Protein

IDBP-174025.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Noa1

Protein Name

RIKEN cDNA 2610024G14 gene

Synonyms

2610024G14Rik; AtNOS1; AU022345; mAtNOS1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045948

InnateDB Gene

IDBG-174021 (Noa1)

Protein Structure

UniProt Annotation

Function

Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. {ECO:0000269PubMed:18456285, ECO:0000269PubMed:21118999}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:16380119, ECO:0000269PubMed:18456285}; Peripheral membrane protein {ECO:0000269PubMed:16380119, ECO:0000269PubMed:18456285}; Matrix side {ECO:0000269PubMed:16380119, ECO:0000269PubMed:18456285}.

Disease Associations

Tissue Specificity

Expressed in tissues associated with high mitochondria content including testes, heart, liver, brain and thymus. Also expressed in various bone cell lines. {ECO:0000269PubMed:16380119}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006915	apoptotic process
GO:0010941	regulation of cell death
GO:0032543	mitochondrial translation
GO:0042254	ribosome biogenesis
GO:0043457	regulation of cellular respiration