InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COBL

Summary

InnateDB Protein

IDBP-16787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COBL

Protein Name

cordon-bleu homolog (mouse)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265136

InnateDB Gene

IDBG-16785 (COBL)

Protein Structure

UniProt Annotation

Function

Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269PubMed:21816349}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003785	actin monomer binding

Biological Process

GO:0000578	embryonic axis specification
GO:0001757	somite specification
GO:0001843	neural tube closure
GO:0001889	liver development
GO:0030041	actin filament polymerization
GO:0030903	notochord development
GO:0033504	floor plate development
GO:0048565	digestive tract development
GO:0048669	collateral sprouting in absence of injury
GO:0051639	actin filament network formation
GO:1900006	positive regulation of dendrite development

Cellular Component

GO:0001726	ruffle
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0044294	dendritic growth cone
GO:0044295	axonal growth cone
GO:0048471	perinuclear region of cytoplasm