Version 5.4
Mus musculus Protein: Cpsf2
Summary
InnateDB Protein IDBP-165432.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpsf2
Protein Name cleavage and polyadenylation specific factor 2
Synonyms 100kDa; 2610024B04Rik; AI662483; Cpsf; MCPSF; mKIAA1367;
Species Mus musculus
Ensembl Protein ENSMUSP00000047797
InnateDB Gene IDBG-165430 (Cpsf2)
Protein Structure
UniProt Annotation
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0006378 mRNA polyadenylation
GO:0006379 mRNA cleavage
GO:0006398 histone mRNA 3'-end processing
Cellular Component
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1861601
InterPro IPR001279 Beta-lactamase-like
IPR011108 RNA-metabolising metallo-beta-lactamase
IPR022712 Beta-Casp domain
PFAM PF00753
PF07521
PF10996
PRINTS
PIRSF
SMART SM00849
SM01027
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35218
PhosphoSite PhosphoSite-O35218
TrEMBL Q8C6K6
UniProt Splice Variant
Entrez Gene 51786
UniGene Mm.716
RefSeq NP_058552
MGI ID
MGI Symbol Cpsf2
OMIM
CCDS CCDS26116
HPRD
IMGT
EMBL AF012822 AK054372 AK140869 AK141325 AK147746 BC007163 BC013628
GenPept AAB66830 AAH07163 AAH13628 BAC35756 BAE24504 BAE24650 BAE28111

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca