InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PABPC3

Summary

InnateDB Protein

IDBP-16533.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PABPC3

Protein Name

poly(A) binding protein, cytoplasmic 3

Synonyms

PABP3; PABPL3; tPABP;

Species

Homo sapiens

Ensembl Protein

ENSP00000281589

InnateDB Gene

IDBG-16529 (PABPC3)

Protein Structure

UniProt Annotation

Function

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis specific. {ECO:0000269PubMed:11328870}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0008143	poly(A) binding

Biological Process

GO:0016071

mRNA metabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
IPR003954 RNA recognition motif domain, eukaryote
IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4

PFAM

PF00076
PF00658

PRINTS

PIRSF

SMART

SM00360
SM00517
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H361